Online Automated Dissolution Systems
- Tablet Dissolution Testing Instruments
- Offline Automated Dissolution Systems
- Online Automated Dissolution Systems
- In-Situ Dissolution Testing (Coming Soon)
- Media Preparation
- UV/VIS Spectrometers
Tablet Dissolution Testing Instruments
A dissolution test is a means of identifying and proving the availability of active pharmaceutical ingredient (API) in their delivered form.
Offline Automated Dissolution Systems
The DFC offline semi-automated dissolution testing systems include a dissolution bath, a pump and a fraction collector which collects the sampled dissolution media.
Online Automated Dissolution Systems
Automated dissolution testing in this case means sampling, measuring, and result calculation are automated. The user adds the samples when prompted to do so by the system and takes care of filling and cleaning of the vessels.
Media Preparation
Media preparation and degassing are vital parts of a tablet dissolution test as deaerated media are critical to the reproducibility of dissolution results.
UV/VIS Spectrometers
UV/VIS Spectrometers for Tablet Dissolution Applications
ADS-L 1420
Fully Automated Tablet Dissolution Testing System
The online dissolution system ADS-L 1420 consists of the 14+2 vessel Pharma Test dissolution tester PTWS 1420, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant user friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.
Technical Specifications ADS-L 1420
Parameter Specification Dissolution Bath PTWS 1420 14+2-position dissolution bath Spectrometer TIDAS L UV/VIS diode-array spectrometer with 14 channel cell changer, 2 additional channels for fiber optic measurements Spectrometer Specifications Wavelength Range 190 – 1100 nm (Spectral resolution ≤ 2 nm); Included light source: 35 W Deuterium/ 7,5 W Halogen
Pump IPC 16 peristaltic pump with 16 channels; adjustable speed 2.5 – 50 rpm
Tubing Color-coded full teflon-PTFE tubing to connect the system Software WinDiss ARGUS dissolution software package + TIDAS DAQ3 PC Windows based integrated PC Tubing Installation Teflon tubing with stainless steel sampling probes Sampling System Resident sampling probes installed onto individual test vessel covers System Dimensions Approx. 2200 x 1000 x 1000 mm (Length x Width x Height) Packaging Dimensions Approx. 1370 x 780 x 870 mm (Length x Width x Height) Net / Gross Weight Approx. 120 kg Certification All instruments and components certified to USP / EP requirements CE / EMC Certification All CE / EMC Certification provided Validation All instrument IQ & OQ documents included (software IQ & OQ documents are available as options)
Drivers Currently Available
| Instrument Category | List of Supported Instruments |
| Drivers for Dissolution Tester | Pharma Test PTWS 120D/S, PTWS 820, PTWS 620, PTWS 1220, PTWS D620, PTWS 1420, IDS 1000, PT-DT8, PTWS 300, PTWS 310, PTWS 610, PTWS 1210, PTWS D610
Hanson SR8 Plus, Vision Elite & Classic 6, Vision G2 Elite & Classic 6 Sotax AT7/AT7smart, AT Xtend; Varian VK70XX Distek 2100, 5100, Evolution series ERWEKA DT800, DT700, DT720 Copley DT600, DT800 |
| Drivers for Spectrophotometers
| Pharma Test TIDAS L, T70, SA500
Agilent 8453, 8454 Agilent/Varian Cary50 J&M Tidas II (9-channel fiber optic) AnalytikJena 200/205/210/250 Beckman DU800 Kontron Uvikon XL Cecil 2000/3000/4000/7000/9000 series PerkinElmer LAMBDA 2/20/25/35/45 Shimadzu UV1700 PharmaSpec, UV1800 Tec5 MultiSpec Thermo Evolution 300 Zeiss MCS5XX, MCS6XX(2-channel fiber optic) |
| Drivers for Pumps | Pharma Test PT-SP6, PT-SP8
ISMATEC IPC/IPC-N Hanson AutoPlus MAXIMIZER, Vision G2 AutoPlus Hamilton Dynamix III Sotax CY-7-50, CP7 Varian Vk806 Watson Marlow 323Du Distek Evolution 4300 Solvias Micamix Dual Syringe |
| Drivers for Dilutor Autosampler & Fraction Collector Driver | Pharma Test DSR-M, PTFC
Gilson 223 (Agilent G1811A) Hanson AutoPlus MultiFill, G2 AutoFill PerkinElmer AS90, AS93plus, S10 Sotax C613/C615 Varian Vk8000 Distek Evolution 4300 Valve Driver Hamilton MVP Rheodyne MX Series II Injector Drivers available on demand Agilent 8452A Beckman Du600 Distek 2230A PerkinElmer L265,365,465 |
Included in the Standard Scope of Supply
- TMA-1420 automated tablet drop magazine
- EPE-1420 automated sampling system
- Cleaning system for tubing lines with magnetic holders
- One set of stainless steel paddles
- One set of batch coded 1000ml Borosilicate glass vessels
- One set of depth adjustment balls
- One bottle of ALGEX Magenta water preservative
- The TIDAS L 570 DAD UV/VIS Spectrometer
- Cuvette changer with 14 positions + 2 additional ports for fiber optic probes
- Integrated Windows PC with large touch screen
- E-Ink display as “smart type plate”
- USB and Ethernet ports for data transfer
- Diode-array detector (DAD) for ultra-fast measurements of the complete spectra
- TIDASDAQ3 software package for manual control of the spectrometer
- 21 CFR part 11 compliant WinDiss ARGUS software for optimized dissolution test procedures
- Comprehensive documentation folder including:
- User manual
- DQ/QC instrument compliance test certificate
- IQ documentation
- OQ documentation
- Instrument logbook
- Compliance certificates for vessels and stirring tools
WinDiss ARGUS Dissolution Software
21 CFR Part 11 compliance as well as compliance to the new requirements for Data Integrity
The WinDiss ARGUS Dissolution Software is a scientific dissolution data management software for instrument control, data acquisition, data management, processing and reporting – designed by users for users. WinDiss ARGUS Dissolution is compatible to almost all dissolution systems in the laboratory. Just one software needs to be trained and qualified. Whether you perform dissolution tests occasionally or several times each day WinDiss ARGUS Dissolution will make you more productive in running tests and analyzing results.
- Automated temperature check and log at all sampling times
- Fully USP <711/724> and EP <2.9.3/4> compliant
- PTWS 120D – 6 stirred positions same speed
- PTWS 120S – individual speed control for each stirrer or grouping like 2×3, 3×2 etc.
- System composed of PTWS 120D or PTWS 120S dissolution bath, PTFC-2/8 fraction collector and PT-SP8 syringe pump. Alternatively Ismatec peristaltic pumps or CAT piston pumps may be used
- Automated withdrawal of samples at specified times via in-situ sampling probes
- Printed test report (PT-RP80 required)
- Automated media refilling
- Connect multiple dissolution test laboratories to one central database
- ARGUS/Dissolution can be used offline to query, review, approve, release and electronically sign methods and analyses.
- Use ARGUS/Dissolution to exchange data with your LIMS or enterprise document management system (EDMS).
- Database Compatibility
- MariaDB
- MySQL
- Microsoft SQL Server
- Oracle
- Additional USP/EP compliance features:
- One or more Q-values for each API
- High/low dissolution boundaries
- USP S1, S2 and S3 testing in one record
ADS-L 120
Fully Automated Tablet Dissolution Testing System
The online dissolution system ADS-L 120 consists of a Pharma Test dissolution tester PTWS 120, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant User friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.
- Automated temperature check and log at all sampling times
- Sampling, measuring, and result calculation are automated
- Online, closed loop system with integrated spectrometer
- Systems composed of Pharma Test PTWS 120D dissolution bath, J&M TIDAS® L 570 DAD UV/VIS spectrometer and IPC peristaltic pump
- Controlled by WinDiss ARGUS PC software
- Easy and effective cleaning procedure
Technical Specifications ADS-L 120
| Parameter | Specification |
| Dissolution Bath | PTWS 120D 6-position dissolution bath |
| Spectrometer | TIDAS® L UV/VIS diode-array spectrometer with 8 channel cell changer, 3 additional channels for fiber optic measurements |
| Spectrometer Specifications | Wavelength Range 190 – 1100 nm (Spectral resolution ≤ 2 nm)
Included light source: 35 W Deuterium/ 7,5 W Halogen |
| Pump | IPC 8 peristaltic pump with 8 channels;
adjustable speed 2.5 – 50 rpm |
| Software | WinDiss ARGUS dissolution software package + TIDAS DAQ3 |
| PC | Windows based integrated PC |
| Tubing Installation | Teflon tubing with stainless steel sampling probes |
| Sampling System | Resident sampling probes installed onto individual test vessel covers |
| System Dimensions | Approx. 1600 x 600 x 800 mm (Length x Width x Height) |
| Packaging Dimensions | Approx. 1000 x 800 x 1000 mm (Length x Width x Height) |
| Net / Gross Weight | Approx. 60 kg |
| Certification | All instruments and components certified to USP / EP requirements |
| CE / EMC Certification | All CE / EMC Certification provided |
| Validation | All instrument IQ & OQ documents included (software IQ & OQ documents are available as options) |
Included in the Standard Scope of Supply
The ADS-L 120 comes ready to use with the following standard scope of supply:
- One set of stainless steel paddles
- One set of batch coded 1000ml Borosilicate glass vessels
- One set of depth adjustment balls
- One bottle of ALGEX Magenta water preservative
- The TIDAS® L 570 DAD UV/VIS Spectrometer
- Cuvette changer with 8 positions + 3 additional ports for fiber optic probes
- Integrated Windows PC with large touch screen
- E-Ink display as “smart type plate”
- USB and Ethernet ports for data transfer
- Diode-array detector (DAD) for ultra-fast measurements of the complete spectra
- TIDASDAQ3 software package for manual control of the spectrometer
- 21 CFR part 11 compliant WinDiss ARGUS software for optimized dissolution test procedures
- Comprehensive documentation folder including:
- User manual
- DQ/QC instrument compliance test certificate
- IQ documentation
- OQ documentation
- Instrument logbook
- Compliance certificates for vessels and stirring tools
ADS-L 820
Fully Automated Tablet Dissolution Testing System
The online dissolution system ADS-L 820 consists of a Pharma Test dissolution tester PTWS 820D, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant user friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.
- Automated temperature check and log at all sampling times
- Sampling, measuring, and result calculation are automated
- Online, closed loop system with integrated spectrometer
- Systems composed of Pharma Test PTWS 820D dissolution bath, J&M TIDAS® L 570 DAD UV/VIS diode array spectrometer and IPC peristaltic pump
- Controlled by WinDiss ARGUS PC software
- Easy and effective cleaning procedure
Technical Specifications ADS-L 820
| Parameter | Specification |
| Dissolution Bath | PTWS 820D 8-position dissolution bath |
| Spectrometer | TIDAS® L UV/VIS diode-array spectrometer with 8 channel cell changer, 3 additional channels for fiber optic measurements |
| Spectrometer Specifications | Wavelength Range 190 – 1100 nm (Spectral resolution ≤ 2 nm);
Included light source: 35 W Deuterium/ 7,5 W Halogen |
| Pump | IPC 8 peristaltic pump with 8 channels;
adjustable speed 2.5 – 50 rpm |
| Tubing | Color-coded full teflon-PTFE tubing to connect the system |
| Software | WinDiss ARGUS dissolution software package + TIDASDAQ3 |
| PC | Windows based integrated PC |
| Tubing Installation | Teflon tubing with stainless steel sampling probes |
| Sampling System | Resident sampling probes installed onto individual test vessel covers |
| System Dimensions | Approx. 1900 x 800 x 750 mm (Length x Width x Height) |
| Packaging Dimensions | Approx. 1100 x 780 x 900 mm (Length x Width x Height) |
| Net / Gross Weight | Approx. 100 kg |
| Certification | All instruments and components certified to USP / EP requirements |
| CE / EMC Certification | All CE / EMC Certification provided |
| Validation | All instrument IQ & OQ documents included (software IQ & OQ documents are available as options) |
Included in the Standard Scope of Supply
The ADS-L 820 comes ready to use with the following standard scope of supply:
- TM-820 manual tablet drop magazine
- EPE-820 automated sampling system
- Cleaning system for tubing lines with magnetic holders
- One set of stainless steel paddles
- One set of batch coded 1000ml Borosilicate glass vessels
- One set of depth adjustment balls
- One bottle of ALGEX water preservative
- The TIDAS L 570 DAD UV/VIS Spectrometer
- Cuvette changer with 8 positions + 3 additional ports for fiber optic probes
- Integrated Windows PC with large touch screen
- E-Ink display as “smart type plate”
- USB and Ethernet ports for data transfer
- Diode-array detector (DAD) for ultra-fast measurements of the complete spectra
- TIDASDAQ3 software package for manual control of the spectrometer
- 21 CFR part 11 compliant WinDiss ARGUS software for optimized dissolution test procedures
- Comprehensive documentation folder including:
- User manual
- DQ/QC instrument compliance test certificate
- IQ documentation
- OQ documentation
- Instrument logbook
- Compliance certificates for vessels and stirring tools
ADS-L 620
Fully Automated Tablet Dissolution Testing System
The online dissolution system ADS-L 620 consists of a Pharma Test dissolution tester PTWS 620, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant user friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.
- Automated temperature check and log at all sampling times
- Sampling, measuring, and result calculation are automated
- Online, closed loop system with integrated spectrometer
- Systems composed of Pharma Test PTWS 620 dissolution bath, J&M TIDAS® L 570 DAD UV/VIS diode array spectrometer and IPC peristaltic pump
- Controlled by WinDiss ARGUS PC software
- Easy and effective cleaning procedure
Technical Specifications ADS-L 620
| Parameter | Specification |
| Dissolution Bath | PTWS 620D 6+2-position dissolution bath |
| Spectrometer | TIDAS® L UV/VIS diode-array spectrometer with 8 channel cell changer, 3 additional channels for fiber optic measurements |
| Spectrometer Specifications | Wavelength Range 190 – 1100 nm (Spectral resolution ≤ 2 nm);
Included light source: 35 W Deuterium/ 7,5 W Halogen |
| Pump | IPC 8 peristaltic pump with 8 channels;
adjustable speed 2.5 – 50 rpm |
| Tubing | Color-coded full teflon-PTFE tubing to connect the system |
| Software | WinDiss ARGUS dissolution software package + TIDAS DAQ3 |
| PC | Windows based integrated PC |
| Tubing Installation | Teflon tubing with stainless steel sampling probes |
| Sampling System | Resident sampling probes installed onto individual test vessel covers |
| System Dimensions | Approx. 1900 x 800 x 750 mm (Length x Width x Height) |
| Packaging Dimensions | Approx. 1100 x 780 x 900 mm (Length x Width x Height) |
| Net / Gross Weight | Approx. 90 kg |
| Certification | All instruments and components certified to USP / EP requirements |
| CE / EMC Certification | All CE / EMC Certification provided |
| Validation | All instrument IQ & OQ documents included (software IQ & OQ documents are available as options) |
Included in the Standard Scope of Supply
The ADS-L 620 comes ready to use with the following standard scope of supply:
- TM-620 manual tablet drop magazine
- EPE-620 automated sampling system
- One set of stainless steel paddles
- One set of batch coded 1000ml Borosilicate glass vessels
- One set of depth adjustment balls
- One bottle of ALGEX water preservative
- The TIDAS® L DAD UV/VIS Spectrometer
- Cuvette changer with 8 positions
- Inbuild Windows PC
- E-Ink Display
- Big touchscreen
- USB Port for data transfer
- DAD detector for ultrafast measurements of the complete spectra
- TIDASDAQ3 software package for manual control of the spectrometer
- 21 CFR part 11 compliant WinDiss ARGUS software for optimized dissolution test procedures
- Comprehensive documentation folder including:
- User manual
- DQ/QC instrument compliance test certificate
- IQ documentation
- OQ documentation
- Instrument logbook
- Compliance certificates for vessels and stirring tools
ADS-L 1220
Fully Automated Tablet Dissolution Testing System
The online dissolution system ADS-L 1220 consists of a Pharma Test dissolution tester PTWS 1220, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant user friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.
- Automated temperature check and log at all sampling times
- Sampling, measuring, and result calculation are automated
- Online, closed loop system with integrated spectrometer
- Systems composed of Pharma Test PTWS 1220 dissolution bath, J&M TIDAS® L 570 DAD UV/VIS diode array spectrometer and IPC peristaltic pump
- Controlled by WinDiss ARGUS PC software
- Easy and effective cleaning procedure
Technical Specifications ADS-L 1220
| Parameter | Specification |
| Dissolution Bath | PTWS 1220 12-position dissolution bath |
| Spectrometer | TIDAS® L UV/VIS diode-array spectrometer with 14 channel cell changer, 2 additional channels for fiber optic measurements |
| Spectrometer Specifications | Wavelength Range 190 – 1100 nm (Spectral resolution ≤ 2 nm);
Included light source: 35 W Deuterium/ 7,5 W Halogen |
| Pump | IPC 16 peristaltic pump with 16 channels;
adjustable speed 2.5 – 50 rpm |
| Tubing | Color-coded full teflon-PTFE tubing to connect the system |
| Software | WinDiss ARGUS dissolution software package + TIDAS DAQ3 |
| PC | Windows based integrated PC |
| Tubing Installation | Teflon tubing with stainless steel sampling probes |
| Sampling System | Resident sampling probes installed onto individual test vessel covers |
| System Dimensions | Approx. 2200 x 1000 x 1000 mm (Length x Width x Height) |
| Packaging Dimensions | Approx. 1370 x 780 x 870 mm (Length x Width x Height) |
| Net / Gross Weight | Approx. 120 kg |
| Certification | All instruments and components certified to USP / EP requirements |
| CE / EMC Certification | All CE / EMC Certification provided |
| Validation | All instrument IQ & OQ documents included (software IQ & OQ documents are available as options) |
