Microplate - Instruments
SmartReader™ Multimode
The Accuris SmartReader™ Multimode is an advanced microplate reader designed to meet the growing needs of advanced life science labs. Equipped with a full suite of high-performance optical systems, the SmartReader Multimode is your all-in-one solution for absorbance, fluorescence and luminescence applications.
The SmartReader Multimode quickly processes assays in standard 96 well plates and can also accept 6, 12, 24, 48 and 384 well plates. Programming and operation are managed from the instrument’s large color touch screen and no external computer or software is required. Optional PC software is available for easy control and data handling via a Windows™ PC. The friendly and intuitive interface guides the user through various options for assay set up and processing. The instrument features a built-in plate shaker with linear, orbital, and double-orbital shaking modes, and an incubator that can perform top heating from ambient + 4°C – 45°C. Top heating creates a temperature gradient to prevent condesnation when lids are used on the microplates. Upon startup, the SmartReader Multimode performs a self-diagnostic test, followed by an automatic calibration of the entire system, ensuring consistent results across a wide range of assays.
UV-Visible Absorbance
Utilizing an advanced monochromator and a long-life, broad-spectrum xenon flash lamp, the SmartReader Multimode can produce incident light at user-selected wavelengths from 200 to 1000 nm in 1 nm steps. Processing assays is fast; a full 96 well plate can be read in under 15 seconds. The kinetic assay feature performs multiple readings over a set period of time, with curves for each well displayed in real-time. The optional SmartDrop™ plate allows fast and convenient UV absorbance evaluation of up to 16 nucleic acid and protein sample droplets.
Absorbance Applications:
- ELISA Assays
- Colorimetrics Assays (Bradford, Lowry, etc.)
- Enzyme Kinetics
- Spectral Scanning
- DNA & RNA Analysis
- …and more
Fluorescence
Three filter modules are included to provide the most common excitation and emission wavelengths needed for fluorescence assays. Additional filter modules are available. These advanced modules incorporate dichroic mirrors with narrow band-pass optical filters and ensure high light transmission, increased detection sensitivity, and are easily exchanged. Modules are barcoded for automatic loading of wavelength data. The SmartReader Multimode allows for automatic dynamic range selection, which allows for the gain of the photomultiplier tube to accurately capture and normalize the signal intensity of samples.
Luminescence
The SmartReader Multimode is capable of luminescent detection, and can process both flash and glow assays. An advanced PMT (photo multiplier tube) enhances sensitivity of weak signals, prevents over-saturation of strong signals, and provides an ideal detection range for all common luminescence applications. Up to 2 sample injectors (available separately) can be installed and are compatible with both 96 and 384-well plates.
Data Transfer & PC Software
Data from the SmartReader Multimode to can be exported as either a .XLS or .CSV file via the included USB flash drive, the FTP server, or by using the optional SmartReader™ PC Software.
The SmartReader PC Software allows for remote programming & operation of the instrument via cable connection. Data from the instrument is automatically uploaded to the connected PC for further analyses. Both a Research version for academic use, and a FDA 21 CFR Part 11 compliant version are available.
| MR9620 | SmartReader™ Multimode Plate Reader, 115V |
| MR9620-E | SmartReader™ MultiMode Plate Reader, 230V |
| MR9620-AIM1 | Automatic Injection Module for MR9620, set of 1 |
| MR9620-AIM2 | Automatic Injection Module for MR9620, set of 2 |
| MR9610-SDP | SmartDrop™ Accessory Plate for UV-Range Microplate Readers |
| MR9620-PC | SmartReader™ PC Software (Research Version) |
| MR9620-CFR | SmartReader™ Multimode PC Security Software (FDA 21 CFR Part 11) |
Model | Accuris SmartReader™ Multimode |
| Measurement Technologies | Absorbance, Fluorescence, Luminescence |
| Plate Formats | 6- to 384-well plates |
| Shaking | Linear (4.7 Hz, 7.0 Hz, 13.5 Hz), orbital and double orbital (240 – 1200 rpm) |
| Incubation Range | RT +4 °C to 45 °C |
| Display | 10.0 inch touchscreen |
| Communication Ports | 2 USB A type ports / 1 USB B type port
1 Ethernet port RS232 interface |
| Dimensions (WxDxH) | 16.5 x 21.7 x 15.2 in.
(42.0 x 55.0 x 38.6 cm) |
| Power Input | AC 100 to 240 V, 50 to 60 Hz |
| Weight | 33 kg / 72.8 lbs |
Absorbance | |
| Light Source | High Energy Xenon Flash Lamp |
| Detector | Photodiode |
| Wavelength Accuracy | 2 nm |
| Wavelength Repeatability | 0.2 nm |
| Bandwidth (FWHM) | > 2.5 nm |
| Wavelength Range | 200 – 1000 nm, 1nm steps |
| Absorbance | 0.0 – 4.0 OD |
| Resolution | 0.0001 OD |
| Accuracy | 96-precision mode:± (1.0 %+0.003Abs)@ (0.0-2.0Abs] ;± 2.0 % @ (2.0-3.0Abs] |
| Repeatability | CV < 1.0 % or SD< 0.003 Fast(0.0-3.0Abs]CV < 0.5 % or SD< 0.003 Accurate(0.0-3.0Abs] |
| Stray Light | 0.1 % @ 220 nm |
| Linearity | R2 > 0.999 @ [0.0-3.0Abs] |
| Measurement Speed | < 15 seconds |
Fluorescence | |
| Reading Mode | Top Reading |
| Excitation Light Source | High Energy Xenon Flash Lamp |
| Detector | Photo Multiplier Tube (PMT) |
| Detection Limit | ≤ 1 pM |
| Wavelength Range | EX: 200 – 1000 nm; EM: 270 – 850 nm |
| Included Filter Cartridges | (EX / EM): 470 / 525nm ; 523 / 564nm ; 624 / 692nm |
| Linear Dynamic Range | 6 logs |
Luminescence | |
| Detector | Photo Multiplier Tube (PMT) |
| Detection Limit | 15 amol / well |
| Linear Dynamic Range | 6 logs |
SmartSeal™ Semi-Automated Microplate Sealer MS1000
The Accuris SmartSeal™ Automated Plate Sealer provides fast, reproducible sealing of microplates. Unlike manual plate sealing, the SmartSeal ensures uniform sealing of all wells and consistency from one plate to the next.
With digital control over all parameters (time, temperature and pressure) the SmartSeal is capable of accepting a wide range of plate types and heights. An aluminum block adapter is included (for assay and PCR plates) increasing the compatibility of the instrument to allow for sealing nearly any plate up to 48mm tall.
With sealing times as low as 5 seconds, the SmartSeal is a time saving solution for labs and production facilities requiring high quality and consistent plate sealing.
Compatible with:
- Deep well (storage) plates up to 48mm tall
- Assay plates
- PCR Plates (skirterd, semi-skirted and non-skirted)
- Polypropylene polystyrene or Polyethylene plates
- Foil or polymer (transparent) seals
SmartSeal Films
- Foil or optically clear films
- Strong thermal bond
- Piecreable and peelable options
- For use with Accuris SmartSeal and other semi-automated thermal plate sealers
The Accuris SmartSeal films are designed for quick and easy sealing of multiwell plates in semi-automated thermal plate sealers. Foil films are ideal for long term storage of samples in polypropylene plates. Able to withstand DMSO and other solvents, the films can be used in freezers and incubators, from -200°C to 110°C. The optically clear films are ideal for use with qPCR and ELISA samples and are compatible with most plate types, including polypropylene, polycarbonate and polyethylene. Peelable, pierceable and strong bonding options are available. Seals are supplied as individual 125x78mm sheets in packs of 100.
| Order No. | Description |
|---|---|
| MS1000 | SmartSeal Semi-Automated Microplate Sealer, 115V |
| MS1000-E | SmartSeal Semi-Automated Microplate Sealer, 230V |
| MS1000-F1 | Foil seals, peelable for PP plates, 100/pk |
| MS1000-F2 | Foil Seals, strong bonding for cold storage (-200 to 110°C) and DMSO, for PP plates, 100/pk |
| MS1000-PCR1 | Optically clear sealing film for qPCR, PEELABLE for most plate types, PP, PC, PE, etc., 100/pk |
| MS1000-PCR2 | Optically clear sealing film for qPCR, STRONG BOND for PP plates, 100/pk |
| MS1000-PCR3 | Optically clear sealing film for qPCR, PIERCEABLE for most plate types, PP, PC, PE, etc., 100/pk |
The Accuris SmartSeal™ Automated Plate Sealer (MS1000) provides fast, reproducible sealing of microplates. Unlike manual plate sealing, the SmartSeal ensures uniform sealing of all wells and consistency from one plate to the next.
- Fast, reproducible sealing of well plates
- Adjustable time, temperature and pressure for optimized sealing
- User friendly controls, load plate and press run to seal
- Accepts a wide range of plate types and heights, including deep well storage plates, assay plates, pcr plates, etc.
Model | Accuris SmartSeal™ |
Temp. Range: | 80°C to 200°C |
Temp. Heat Up: | 6 minutes to reach 200°C |
Temp. Accuracy: | 1°C |
Sealing Time: | 0.5 sec. to 10 sec. (0.1 sec. increments) |
Max. Plate Height: | 48mm |
Dimensions | 17.8 x 37 x 33 cm / 7 x 14.6 x 13 in. |
Weight: | 9.5 kg / 21 Lbs |
Electrical: | 115V or 230V, 50-60Hz, 300W |
SmartReader UV-Vis
Monochromator technology … no filters needed
The monochromator-based optical system allows for precise selection of wavelengths from 200nm to 1000nm, with no filters required. This range makes the SmartReader UV-Vis™ useful not only for typical ELISA , Bradford Lowry, and turbidity assays but also for more advanced applications such as quantitation of nucleic acids and proteins. The SmartReader™ UV-Vis can be set for Endpoint, Kinetic and Spectral Scanning assays.
High Throughput Capability
The MR9610 is designed for efficient processing of multiple samples and
accepts standard 96 well plates as well as 384 well plates for high density
screening. The plate layout interface allows for a quick and intuitive setup of a plate well’s contents. Users can highlight and label multiple wells to save time. The display shows a graphical representation of the plate. Users can label each well as required for: “known standard”, “unknown sample”, “blank well” , “QC Control well”, “positive control”, “negative control”, and “empty”.
Optimized results with plate shaking and incubation
Controllable plate shaking and incubation allow for optimization of assay results. The shaking speed can be controlled at different intensities with options for timed and pulsed shaking before a reading, or in between readings when performing a kinetic assay. The linear motion efficiently and uniformly mixes all samples in both 96 and 384 well plates. Temperature can be controlled from ambient +5⁰C up to 45⁰C, allowing for the processing of enzyme kinetics, and bacterial growth assays.
SmartDrop™ Accessory Plate
Absorbance measurements of exceptionally small volumes (<0.5ul) can be achieved using the SmartDrop™ Accessory Plate. The SmartDrop™ plate accommodates up to 16 samples and is ideal for checking nucleic acid concentrations and purity for Next Gen Sequencing, or protein concentrations.
| Order No. | Description |
|---|---|
| MR9610 | SmartReader™ UV-Vis Microplate Absorbance Reader, 115V |
| MR9610-E | SmartReader™ UV-Vis Microplate Absorbance Reader, 230V |
| MR9611 | SmartReader™ UV-Vis Microplate Absorbance Reader with Cuvette Port, 115V |
| MR9611-E | SmartReader™ UV-Vis Microplate Absorbance Reader with Cuvette Port, 230V |
| MR9610-SDP | SmartDrop Accessory Plate |
| MR9610-PC | SmartReader™ UV-Vis PC Software |
The Accuris SmartReader™ UV-Vis Microplate Readers (models MR9610 and MR9611) have been designed with ease-of-use and fast results in mind. These instruments brings extensive capabilities to the lab bench and are designed for the busy lab with multiple users. A large touch screen command center is extremely user-friendly and allows for fast set up of new protocols, as well as modifying and running existing protocols.
Intuitive, 10-inch color touch screen control panel
Accepts both 96 & 384-well plates
Monochromator-based system
• No filters required
• Wavelength range from 200 to 1000 nmStand-alone design
• No PC or special software required
• USB port for flash drive data transferMR9611 model includes a port for standard cuvette spectroscopy
Model | Accuris SmartReader UV-Vis |
Plates Accepted | 96-well and 384-well flat bottom (cuvettes accepted in MR9611 model) |
Display | 10-inch color touch screen |
Controls | Touch screen and mouse |
Light Source | Xenon Flash Lamp |
Wavelength range | 200-1000nm |
Wavelength Precision | ± 2 nm |
Wavelength Accuracy | ± 2 nm |
Wavelength selection | Monochromator |
Read-out range | 0 – 4.0 OD |
Detector | Dual silicon photoelectric detectors for measurement and reference |
Linearity @ 450nm | R2 ≥ 0.999, [0.0 – 3.0] |
Accuracy @ 450nm | 1.0% + 0.003 Abs (0 – 2.0]2.0% (2.0 – 2.5 Abs] |
Precision@450nm | CV < 0.5% or SD<0.003 (Precision mode); CV < 1.0% (Fast mode) |
Stability@450nm | < 0.005A , (0.0 – 2.0]< 2% (2.0 – 2.5 Abs) |
Measurement speed | 96 well plate: <6 seconds (fast mode); <25 seconds (precision mode)384 well plate: <74 seconds (only precision mode available for 384) |
Plate shaking | Linear; three levels of shaking speed |
Incubator | From ambient + 5℃to 45℃ |
Temperature Uniformity | ± 0.5℃ @ 37℃ |
Storage | 16G memory, more than 10,000 test records can be stored |
Connection Ports | 3 USB ports, for PC, printer and USB-flash drive |
Power supply | DC24V 6.5A |
Dimensions(W×D×H) | 300×500×260mm / 11.8 x 19.7 x 10.25 inches |
Weight | 15.5kg / 34 Lbs |
SmartWasher 96 Microplate Washer
Research requires flexibility – the SmartWasher™ 96 provides it. Full plates, partial plates, and strips with U, V, C, or flat bottoms are accepted by this fully automated washer. Multiple aspiration point settings allow for minimal residual liquid in the wells after aspiration. All parameters, including dispense volume, suction time, soak and shake cycles, and shaking speed are easily programmed using the large 4.3” LCD display and keypad. Up to 100 wash protocols can be stored on board the SmartWasher™ 96 and recalled when needed, or transferred between machines with a flash drive.
The washer comes equipped with 2 wash bottles, 1 rinse bottle and a waste bottle. All have sensors that alert the user when the solutions are low, or in the case of the waste bottle, when it needs to be emptied. An auto-rinse function primes the dispensing tube and wash heads to prevent cross contamination and clogs.
8- and 12-channel manifolds (purchased separately) accommodate plates in either orientation. A transparent, acrylic shield surrounds the wash area, allowing for visualization of the plate. Should a spill or leak occur, the beveled spill well ensures that the liquid is extracted immediately to avoid cross-contamination.
The SmartWasher™ 96 is the perfect partner for the SmartReader™ 96 Microplate Absorbance Reader as well as other popular readers.
| Order No. | Description |
|---|---|
| MW9600 | SmartWasher™ 96 Microplate Washer for 96 Well Plates, manifolds not included, 115V |
| MW9600-E | SmartWasher™ 96 Microplate Washer for 96 Well Plates, manifolds not included, 230V |
| MW9600-12CM | 12 Channel Manifold for MW9600 |
| MW9600-8CM | 8 Channel Manifold for MW9600 |
| MW9600-WSHB | Extra Wash Bottle Assembly for MW9600 |
| MW9600-WSTB | Extra Waste Bottle Assembly for MW9600 |
Model | Accuris SmartWasher 96 |
Control and Display | 4.3-inch LCD display |
Wash Heads | 8 channel or 12 channel |
Wash Modes | 1 point, 2 point, or 3 point aspiration |
Compatible Microplates | 96 wells, standard SBS dimensions |
Residual Liquid Volume | ≤ 1ul (each well) |
Dispensing Volume | 50ul – 2000 ul |
Wash Cycles | 1 ~ 99 cycles |
Program Storage Capacity | 100 programs |
Rinse Function Time Range | 00:00 ~ 03:59 (mm : ss) |
Soak and Shaking Time Range | 00:00 ~ 99:00 (mm : ss) |
Wash Bottle Level Warning | Yes, sensors included in wash and rinse bottles |
Wash Solution Channels | 3 bottles |
Waste Bottle Level Warning | Yes; sensors detect when waste bottle is full |
Waste Aspiration | Yes |
Dimensions | 345 x 460 x 200 mm / 13.5 x 18 x 8.5 inches |
Weight | 11.5 kg / 25.3 Lbs |
SmartReader 96, Microplate Absorbance Reader
The SmartReader 96 comes complete with 4 popular filters: 405,450,492,630nm and twenty six additional filters are available separately to cover a full range from 340 to 750nm. The integrated filter wheel allows up to 8 filters to be loaded at once, and filters can be selected during programming
Use the touch screen, or connect a mouse for programming and operation. The menu interface allows the user to choose the wavelength filter, set shaking parameters, enter details of the plate layout, and also choose the details for the reading protocol and data calculations.
Model MR9600-T offers precise temperature control for incubation of plates during processing. Temperature can be maintained at 5°C above ambient to 50°C.
Up to two filters can be used for 2 measurements of the sample plate, for calculated comparisons. Kinetic calculations can be performed by setting multiple readings.
The SmartReader 96 is a convenient stand alone reader, all software and the programing system is incorporated into the electronics. However, a convenient USB port on the side allows quick and easy saving of data files to a USB drive, and the universal .csv files can then be shared or transferred to a computer for storage or further processing. A data port can be used for connecting a computer or basic printer.
The plate layout interface allows for quick and intuitive set up of a plate’s well contents. The display shows a graphical representation of the 96 well plate, and the user can label each well as required for: “known standard”, “unknown sample”, “blank well”, “QC control well”, “negative control”, “positive control”, or “empty”. The interface allows highlighting and labeling multiple wells to save time.
Measurement data is available immediately on the screen after a reading, as well as interpretations, calculated analysis and curve fittings.
Newly available PC software is compatible with Windows computers for programming and controlling the MR9600 remotely. Click here to download a trial version of our software.
MR9600-CAL Calibration Plate
If performance verification or calibration is required, we offer this service through our Service Department. Or for routine, in-lab verification and calibration we offer a calibration plate (part no. MR9600-CAL). This plate incorporates a range of neutral density filters as well as features to check
- plate positioning
- cross talk
- absorbance accuracy
- precision and linearity
- infrared jamming
- 0 OD and overflow
The SmartReader™ 96 has been cited in numerous papers, published in respected scientific journals. Click here for an abbreviated list of published papers where our SmartReader™ 96 was used during the research.
| MR9600 | Accuris SmartReader 96 Microplate Absorbance Reader, includes 405, 450, 492 and 630nm filters, 115V |
| MR9600-E | Accuris SmartReader 96 Microplate Absorbance Reader, includes 405, 450, 492 and 630nm filters, 230V |
| MR9600-T | Accuris SmartReader 96 with incubation, includes 405, 450, 492 and 630nm filters, 115V |
| MR9600-T-E | Accuris SmartReader 96 with incubation, includes 405, 450, 492 and 630nm filters, 230V |
| MR9600-TP | Thermal Printer for MR-9600 |
| MR9600-PA | Extra paper rolls for MR9600-TP printer, pk/4 |
| MR9600-CAL | Calibration and Performance Verification Plate for MR9600 |
| MR9600-PC | SmartReader PC Software for MR9600 and MR9600-T |
| MR9600-340 | Filter for Accuris Microplate Reader, 340nm |
| MR9600-380 | Filter for Accuris Microplate Reader, 380nm |
| MR9600-405 | Filter for Accuris Microplate Reader, 405nm |
| MR9600-415 | Filter for Accuris Microplate Reader, 415nm |
| MR9600-420 | Filter for Accuris Microplate Reader, 420nm |
| MR9600-450 | Filter for Accuris Microplate Reader, 450nm |
| MR9600-470 | Filter for Accuris Microplate Reader, 470nm |
| MR9600-492 | Filter for Accuris Microplate Reader, 492nm |
| MR9600-510 | Filter for Accuris Microplate Reader, 510nm |
| MR9600-520 | Filter for Accuris Microplate Reader, 520nm |
| MR9600-532 | Filter for Accuris Microplate Reader, 532nm |
| MR9600-540 | Filter for Accuris Microplate Reader, 540nm |
| MR9600-546 | Filter for Accuris Microplate Reader, 546nm |
| MR9600-560 | Filter for Accuris Microplate Reader, 560nm |
| MR9600-562 | Filter for Accuris Microplate Reader, 562nm |
| MR9600-570 | Filter for Accuris Microplate Reader, 570nm |
| MR9600-578 | Filter for Accuris Microplate Reader, 578nm |
| MR9600-590 | Filter for Accuris Microplate Reader, 590nm |
| MR9600-595 | Filter for Accuris Microplate Reader, 595nm |
| MR9600-600 | Filter for Accuris Microplate Reader, 600nm |
| MR9600-620 | Filter for Accuris Microplate Reader, 620nm |
| MR9600-630 | Filter for Accuris Microplate Reader, 630nm |
| MR9600-650 | Filter for Accuris Microplate Reader, 650nm |
| MR9600-663 | Filter for Accuris Microplate Reader, 663nm |
| MR9600-680 | Filter for Accuris Microplate Reader, 680nm |
| MR9600-690 | Filter for Accuris Microplate Reader, 690nm |
| MR9600-700 | Filter for Accuris Microplate Reader, 700nm |
| MR9600-750 | Filter for Accuris Microplate Reader, 750nm |
Model | Accuris SmartReader 96 |
Control and Display | 7 inch touch screen(800 x 480 pixels) |
Light Source | Quartz-halogen lamp 6V/10W |
Wavelength range | 340-750nm (405, 450, 492and 630 nm filters included) |
Half-Bandwidth of filters | 3~9nm |
Readout Range | 0~4.000 Abs |
Linearity (405nm) | 0~2.000 Abs <+1% |
0~4.000 Abs <+2% | |
Precision | CV</= 0.2% (0-3) Abs |
CV</= 01.0% (3-4) Abs | |
Test Speed | <6 sec. for 96 well plate |
Incubator (MR9600-T) | Temp control from ambient +5°C to 50°C |
Shaking | 3 modes: slow (3.5Hz), medium (4.7Hz), fast (7.0Hz) |
User Interface | Integrated software,touch screen control |
Storage | 200 programs,100,000 test records |
Ports | USB ports for PC, printer,mouse and flash drive |
Dimensions | 29.5 x 44.0 x 22.5 cm11.6 x 17 x 8.75 inches |
Weight | 10 kg |
Warranty | 2 Years |
