BEAD MILL HOMOGENIZER

HOMOGENIZER​S

Bead Ruptor 4

The Bead Ruptor 4 vigorously and uniformly shakes up to 4 tubes at a time providing an efficient, consistent homogenization and high-yield.

Bead Ruptor 12

The Bead Ruptor 12 vigorously and uniformly shakes up to 16 tubes at a time providing an efficient, consistent homogenization and high-yield.

Bead Ruptor Elite

The Bead Ruptor Elite is specifically designed for grinding, lysing, and homogenizing biological samples prior to molecular extraction.

Bead Ruptor 96

The Bead Ruptor 96 is designed to support traditional milling, cryo-milling, well plate and tube-based bead homogenizing in a single, compact bench-top instrument

BR Cryo Cooling Unit

The BR-Cryo Cooling Unit is compatible with the Bead Ruptor 24 and is designed to prevent the increase of sample temperature during the homogenization process.

Bead Ruptor 4 (Bead Mill Homogenizer)

Bead Ruptor 4 Homogenizer

The Omni Bead Ruptor 4 is the newest addition to the Omni line of Bead Ruptor bead mill homogenizers. Built upon the innovative design and unsurpassed quality of Omni’s Bead Ruptor family, the Bead Ruptor 4 provides powerful performance in a compact design.

Using disposable sample tubes pre-filled with a variety of lysing beads, the Bead Ruptor 4 vigorously and uniformly shakes up to 4 tubes at a time providing an efficient, consistent homogenization and high-yield. The Omni Bead Ruptor 4 is an ideal solution for releasing DNA, RNA, proteins and enzymes from very tough and small samples while still retaining molecular integrity.

Benefits of the Bead Ruptor 4 Homogenizer include:

  • Simultaneously homogenize up to 4 x 2mL, 0.5mL tubes , 4 x 1.5 mL or 1 x 7 mL tubes (7 mL tube carriage sold separatly)
  • Convenient front-loading tube holder position for ease of use and optimal bead/sample interactions
  • Processing range is ideal for soft tissue samples
  • No cool-down required between runs = non-stop processing
  • Disposable tubes ensure no threat of cross-contamination
  • No sample degradation due to quick processing
  • Smaller footprint to maximize bench space

Wide range of bead kits for any sample typeWide range of bead kits for any sample type

 Omni International offers users ultimate flexibility with a range of bead beating tubes and lysing matrices to support homogenization of any sample type.

 


 Bead Ruptor 96Bead Ruptor EliteBead Ruptor 12Bead Ruptor 4
Maximum Sample Capacity57696164
Tube Capability0.5, 1.5, 2 mL0.5, 1.5, 2, 7, 15, 30, 50 mL0.5, 1.5, 2, 7 mL0.5, 1.5, 2, 7 mL
Well Plates
Speed Control3 – 30 Hz0.8 – 8 ms0.8 – 6 ms1 – 5 ms
Run Time5sec – 99min1sec – 9.59min1sec – 9.59min1sec – 5min
Processing Range25 µl – 50 mL25 µl – 50 mL25 µl – 7 mL25 µl – 7 mL
Savable Protocols
Weight92 lb65 lb65 lb16.5 lb
InchesW: 15, H: 17, L: 9.5W: 15, H: 17, L: 13W: 15, H: 17, L: 13W: 10, H: 8.5, L: 11.5
Touch Screen
 VIEW PRODUCTVIEW PRODUCTVIEW PRODUCT 

Ordering Information: Includes Bead Ruptor 4 Drive Unit, integrated 2/1.5/0.5 mL tube carriage, user manual and 1-year warranty. Note: 7 mL tube carriage sold separately.

  • Processing Range:25 micro-liters to 7.0 mL
  • Power Rating:100-230 VAC/ 50-60Hz
  • Dimensions:L: 10in(25.4cm), W: 8.5in(21.5cm), H: 11.5in(29.2cm)
  • Product Weight:16.5 lbs. (7.48kg)
  • Compliance:CE Compliance
  • Run Time:1 sec. to 5 min
  • Performance Range:1 m/s – 5 m/s in increments of 1 m/s
  • Number of Cycles:1
  • Warranty:One Year

Bead Ruptor 12 Bead Mill Homogenizer

Bead Ruptor 12 Homogenizer

The Bead Ruptor 12 is the most powerful and economical bead mill homogenizer available today. It is an ideal solution for a variety of applications that require grinding, lysing, and homogenization of biological samples prior to molecular extraction.

Using disposable sample tubes pre-filled with a variety of lysing beads, the Bead Ruptor 12 vigorously and uniformly shakes up to 16 tubes at a time providing an efficient, consistent homogenization and high-yield. Unlike most other bead mill homogenizers, the Bead Ruptor 12 does not require a cool down period between runs. This means more samples can be processed in a smaller amount of time.

Benefits of the Bead Ruptor 12 Homogenizer include:

  • Simultaneously homogenize up to 12 x 2mL or 0.5mL tubes and 4 x 7mL tubes
  • Convenient front-loading tube holder position for ease of use and optimal bead/sample interactions
  • Processing range is ideal for soft tissue samples
  • No cool-down required between runs = non-stop processing
  • Disposable tubes ensure no threat of cross-contamination
  • No sample degradation due to quick processing
  • Features and integrated lid lock

Compelling performance at a compelling price

The Bead Ruptor 12 is designed with a unique  tube carriage motion to ensure that the intra-tube bead movement reduces swirling and results in the  a high bead impact force. The Bead Ruptor 12 is more powerful than  competitor bead mills that are twice the cost making it an excellent solution for any lab working with tissues or cellular material.

Processing G-Force Range ComparisonBead impact forces generated by commercially available bead mills.  Bead impact forces are calculated as a function of tube acceleration, tube displacement and the motor force applied to the tube. The Bead Ruptor 12 and Bead Ruptor Elite have the broadest force range and produce the highest impact forces of any bead mill on the market. This results in an increased processing efficiency on the Bead Ruptor platforms

 

Unique snap in tube carriage design

The Bead Ruptor 12 eliminates the tedious task of screwing down finger plates  which are present other bead mills. The patent pending snap in tube carriage allows tubes to be “snapped in” and “snapped out” easily thus decreasing  workload and increasing safety. The Bead Ruptor 12 is an ideal bead mill for core laboratories or as a shared resource with its short learning curve and ease of use.

 

Wide range of bead kits for any sample typeWide range of bead kits for any sample type

 Omni International offers users ultimate flexibility with a range of bead beating tubes and lysing matrices to support homogenization of any sample type.

 

 Bead Ruptor 96Bead Ruptor EliteBead Ruptor 12Bead Ruptor 4
Maximum Sample Capacity57696164
Tube Capability0.5, 1.5, 2 mL0.5, 1.5, 2, 7, 15, 30, 50 mL0.5, 1.5, 2, 7 mL0.5, 1.5, 2, 7 mL
Well Plates
Speed Control3 – 30 Hz0.8 – 8 ms0.8 – 6 ms1 – 5 ms
Run Time5sec – 99min1sec – 9.59min1sec – 9.59min1sec – 5min
Processing Range25 µl – 50 mL25 µl – 50 mL25 µl – 7 mL25 µl – 7 mL
Savable Protocols
Weight92 lb65 lb65 lb16.5 lb
InchesW: 15, H: 17, L: 9.5W: 15, H: 17, L: 13W: 15, H: 17, L: 13W: 10, H: 8.5, L: 11.5
Touch Screen
 VIEW PRODUCTVIEW PRODUCT VIEW PRODUCT

Ordering Information: Includes Bead Ruptor 12 Drive Unit, tube carriage, user manual and 1-year warranty.

SPECIFICATIONS
  • Processing Range: 25 micro-liters to 5.0 mL
  • Power Rating: 100-230 VAC/ 50-60Hz
  • Dimensions:L: 15in(38.1cm), W: 17in(43.18cm), H: 13in(33.0cm)
  • Product Weight: 65 lbs. (30kg)
  • Compliance: CE Compliance
  • Run Time: 1 sec to 9:59 min
  • Performance Range: 0.8m/s – 6m/s in increments of 0.8m/s
  • Number of Cycles: 1-10
  • Warranty: One Year

Bead Ruptor Elite (Bead Mill Homogenizer​)

Bead Ruptor Elite

Sample Preperation made easy.

Lyse the toughest samples in seconds with The Bead Ruptor Elite. The Bead Ruptor Elite is the most advanced and easy to use bead mill homogenizer available. It is specifically designed for grinding, lysing, and homogenizing biological samples prior to molecular extraction.

  • Wide range of accessories for any sample size – 24 x 0.5 mL, 24 x 1.5 mL, 24 x 2 mL, 12 x 7 mL, 3 x 15 mL, 6 x 30 mL, 3 x 50 mL, or 96-well strip well tubes.
  • Most powerful bead mill on the market – homogenize the most challenging samples
  • New touch screen interface. Sample Preparation at your finger tips.
  • OptimateTM sample prep software
  • No cool down required between runs: process hundreds of samples per day
  • Convenient front loading design, 99 programmable memory settings, and multilingual user interface
  • Features an integrated lid lock to prevent lid opening during operation
  • The ideal homogenizer for preparing samples when extracting DNA, RNA, proteins, and small molecules
  • Optimized tube motion ensures highest performance

 

The Bead Ruptor Elite is designed with a unique carriage motion to ensure that the intra-tube bead movement reduces swirling and results in the highest bead impact forces of any bead mill on the market. The increased power of the Bead Ruptor Elite decreases processing time and reduces sample heating to maximize sample preparation efficiency.

 

Processing G-Force Range Comparison

Processing G-Force Range Comparison Bead impact forces generated by commercially available bead mills. Bead impact forces are calculated as a function of tube acceleration, tube displacement and the motor force applied to the tube. The Bead Ruptor 12 and Elite have the broadest force range and produce the highest impact forces of any bead mill on the market. This results in an increased processing efficiency on the Bead Ruptor platforms.

 

Increase protein, DNA and RNA yields with the Bead Ruptor Elite

The Bead Ruptor Elite unique tube carriage motion coupled with sample specific bead beating materials  ensure that a thorough homogenate is achieved regardless of the sample type. The high lysing efficiency of the Bead Ruptor Elite results in a increase in nucleic acid, protein and small molecules yields and increases the sensitivity of the downstream assay.
 

OMNI vs Dounce Yield

Total mRNA yields and relative purity; Absorbance values at 260 nm and 280 nm were used to determine total mNRA yield and puity following extraction. mRNA yields where on average 4 times higher when bead milling was performed compared to dounce homogenization. Nucleic acid relative purity was comparable between both methods.

 


Figure 1

Drosophila protein extracts analyzed by SDS PAGE. Lane 1:Protein ladder. Lane 2-3:30 mg of Drosophila homogenate. Lane 4-5:30 mg of Drosphila homogenate.
 

Wide range of bead kits for any sample type


Omni International offers users ultimate flexibility with a range of bead beating tubes and lysing matrices to support homogenization of any sample type.


Ordering Information: Bead Ruptor Drive Unit, user manual and 1-year warranty.


Note: Bead Ruptor Tube Carriages sold separately.

 


 Bead Ruptor 96Bead Ruptor EliteBead Ruptor 12Bead Ruptor 4
Maximum Sample Capacity57696164
Tube Capability0.5, 1.5, 2 mL0.5, 1.5, 2, 7, 15, 30, 50 mL0.5, 1.5, 2, 7 mL0.5, 1.5, 2, 7 mL
Well Plates
Speed Control3 – 30 Hz0.8 – 8 ms0.8 – 6 ms1 – 5 ms
Run Time5sec – 99min1sec – 9.59min1sec – 9.59min1sec – 5min
Processing Range25 µl – 50 mL25 µl – 50 mL25 µl – 7 mL25 µl – 7 mL
Savable Protocols
Weight92 lb65 lb65 lb16.5 lb
InchesW: 15, H: 17, L: 9.5W: 15, H: 17, L: 13W: 15, H: 17, L: 13W: 10, H: 8.5, L: 11.5
Touch Screen
 VIEW PRODUCT VIEW PRODUCTVIEW PRODUCT
SPECIFICATIONS
  • Processing Range: 25 micro-liters to 50mL
  • Power Rating: 100-230 VAC/ 50-60Hz
  • Dimensions:L: 15in(38.1cm), W: 17in(43.18cm), H: 13in(33.0cm)
  • Product Weight: 65 lbs. (29kg)
  • Compliance: CE Compliance
  • Run Time:1 second to 9:59 minutes
  • Performance Range: 0.8m/s – 8m/s in increments of 0.15m/s
  • Number of Cycles:1-10
  • User Interface: Touchscreen with user defined programs, tube configuration and parameter control
  • Safety: Integrated lid lock to prevent lid opening during operation
  • Warranty: One Year

Bead Ruptor 96 Well Plate Homogenizer

Bead Ruptor 96 Well Plate Homogenizer

Versatility Realized. Throughput Enabled

The Bead Ruptor 96 is our most versatile homogenizer. The Bead Ruptor 96 is designed to support traditional milling, cryo-milling, well plate and tube-based bead homogenizing in a single, compact bench-top instrument. The Bead Ruptor 96 is ideal for labs requiring high throughput bead mill processing with the capability to dissociated up to 384 samples per processing cycle. With the stainless steel jar accessories, the Bead Ruptor 96 is capable of performing all milling applications, including dry grinding of grains, powder particle size reduction, dissociation of plastics, plants, seeds, paper products, and drugs. In addition, with the cryogenic processing capabilities, the Bead Ruptor 96 is ideal for cannabis processing, with the ability to rapidly dissociate cannabis flowers and edibles.

Features

  • Multiple sample processing modes including:
    • Sealed stainless steel jar milling in volumes up to 50 mL
    • Cryogenic milling in stainless steel jars for dissociation of tough materials or heat sensitive analytes
    • Well plate homogenizing in standard SBS format 1 mL, 2 mL and standard well plates.
    • Bead beating in sealed micro centrifuge or screw cap tubes up to 48 samples per run
  • High throughput processing: Dissociate up to 384 samples per cycle
  • Digital controls ensure reproducibility
  • Large processing swath ensures high impact forces to dissociate even the toughest samples
  • 30 Hz frequency ensures rapid sample processing.
  • Accessories for dry, wet or cryo-grinding
  • Integrated safety lid
  • Wide range of accessories including well plate adaptors, tube holders and sealed jars for wet, dry or cryogenic milling.

Ideal for

  • High-throughput bead beating in 2 X 2 mL deep well plates, 4 X 1 mL well plates or 6 X standard well plates
  • Dry grinding of powders, ceramics, bones, feed materials, plastics, paper products, textiles and ores
  • Cryogenic milling of tough materials including plastics, plants, tissues, and bone
  • Cryogenic milling of cannabis edibles, gummy candies, suckers or sticky materials
  • Rapid DNA, RNA or protein extraction from a wide range of materials
  •  

 Bead Ruptor 96Bead Ruptor EliteBead Ruptor 12Bead Ruptor 4
Maximum Sample Capacity57696164
Tube Capability0.5, 1.5, 2 mL0.5, 1.5, 2, 7, 15, 30, 50 mL0.5, 1.5, 2, 7 mL0.5, 1.5, 2, 7 mL
Well Plates
Speed Control3 – 30 Hz0.8 – 8 ms0.8 – 6 ms1 – 5 ms
Run Time5sec – 99min1sec – 9.59min1sec – 9.59min1sec – 5min
Processing Range25 µl – 50 mL25 µl – 50 mL25 µl – 7 mL25 µl – 7 mL
Savable Protocols
Weight92 lb65 lb65 lb16.5 lb
InchesW: 15, H: 17, L: 9.5W: 15, H: 17, L: 13W: 15, H: 17, L: 13W: 10, H: 8.5, L: 11.5
Touch Screen
  VIEW PRODUCTVIEW PRODUCTVIEW PRODUCT
SPECIFICATIONS
  • Processing Range:<25µL-50ml
  • Power Rating:100-230 VAC / 50-60 Hz
  • Speed Control:Variable from 3 to 30 Hz
  • Run Time:5 sec to 99 min
  • Dimensions:15″ W x 17″ D x 9.5″ H
  • Weight:42kg (92 lbs.)
  • Sound Level:< 72 db. 
  • Warranty:One year motor warranty 
  • Standards Approval:CE approved

 

 

27-106

Microtube or Screw Cap Tube Holder

 

 

 

 

 

 

 

 

 

19-610

Hard Tissue Grinding Mix (1.5 mL)

 

 

 

 

 

 

27-520

10 Pack 96 Well Plates

 

 

 

 

 

 

27-530

10 Pack Sealing Mats

 

 

 

 

 

 

 

 

 

27-101

Well Plate Adapter

Omni Bead Ruptor 24 Cryo Cooling Unit

Cooling system to protect heat sensitive samples during homogenization

The BR-Cryo Cooling Unit is compatible with the Bead Ruptor 24 and is designed to prevent the increase of sample temperature during the homogenization process. Friction generated through the bead milling process generates heat that is imparted to the sample. In order to maintain a constant processing temperature during homogenization, the BR-Cryo passes chilled air (-100°C to -50°C) into the sample processing chamber and across the sample tubes to dissipate heat.

Samples can be maintained at a temperature ranging from 4°C to ambient thus protecting heat sensitive samples such as RNA and proteins. 

The BR-Cryo can be used to maintain a constant temperature when extracting functional enzymes or volatile small molecules.

 

Cryo Cooling Unit Process Time

Intra-tube temperature monitoring during bead mill homogenization. 2 mL Omni reinforced tubes containing five 2.8 mm ceramic beads (Cat # 19-628) were filled with 1 mL H2O and processed  at 7 m/s on the Bead Ruptor 24 for increasing time periods. Homogenization was performed with and without the use of the BR-Cryo cooling unit using liquid nitrogen as the cryo source. Intra-tube temperatures were monitored at each time point.

Bead Ruptor 24 Cryo Cooling Unit  Overview

  • Compatible with the Bead Ruptor 24
  • Adjustable cooling rate
  • Compatible with liquid nitrogen or dry ice with ethanol
  • BR-Cryo maintain sample temperatures from 4°C to ambient
  • Prevent protein degradation
  • Ensure RNA stability
  • Prevent enzyme activation
  •  

Laboratory Requirements

  • Compressed dry medical grade air
  • Compressed air  flow rate must be at 120 PSI
  • Liquid nitrogen or dry ice in ethanol (liquid nitrogen is preferred)
SPECIFICATIONS
  • Dimensions:29.2 (high) x 34.3 (deep at base) / 20.3 (deep at top) x 22.9 wide cm
  • Weight:7.2 kg (16 lbs)
  • Cryo Chamber Volume: 1 L
  • Air Source Requirements:Compressed medical dry air (water < 5ppm)
  • Air Source Pressure:120 PSI
  • Cooling Source:Liquid Nitrogen or dry ice in ethanol
  • Liquid Nitrogen Consumption:1 L  per 5 min of homogenization time
  • Dry Ice Consumption:1 L of 0.5 L ethanol + 0.5 L dry ice per 90 minutes of homogenization time
  • Tube Compatibility:With 1.5 mL, 2 mL and 7 mL tube carriages only. Not compatible with tube sizes >7 mL
  • Instrument Compatibility:BR Cryo is compatible with Bead Ruptor Elite (19-040E)
  • Warranty:One year